CERCANDO UNA SOLUZIONE PER LA SINDROME DEL GOLFO...

DIPARTIMENTO DELLA DIFESA
DOI: (U) 940611
REQS: (U) [ b.2 ]
FONTE: (U) FONTE PUBBLICA, LETTERA RICEVUTA DA UNO SCIENZIATO CON ACCESSO DIRETTO ALL' INFORMAZIONE FORNITA. L'ATTENDIBILITA' DELL'INFORMAZIONE E' NON PROVATA.
RIASSUNTO: (U) UNO SCIENZIATO NORVEGESE AFFERMA DI AVER AVUTO SINTOMI SIMILI A QUELLI DELLA SINDROME DELLA GUERRA DEL GOLFO.
I SINTOMI SONO STATI TRATTATI CON ALTI DOSAGGI DI UN ANTIDOTO E DOPO DUE (2) ANNI IL PAZIENTE E' SIGNIFICATIVAMENTE MIGLIORATO. ALLEGATI.
TESTO: 1 (U) IL DOTTOR OLAV ALBERT ( (CHRISTOPHERSEN) ) , UNO SCIENZIATO NORVEGESE, AFFERMA IN UNA LETTERA CHE LUI E SUA MOGLIE SI SONO AMMALATI NEL 91 DOPO L'INGESTIONE DI UN LIPIDO-SOLUBILE ANTIOSSIDANTE SINTETICO CONTENENTE ETHOXYQUIN. IL PROFESSOR IVAR ( (OYE) ), CHE LAVORA ALL'ISTITUTO DI FARMACOLOGIA DELL'UNIVERSITA' DI OSLO HA CURATO ENTRAMBE LE PERSONE CON UN ANTIDOTO PER UN PERIODO DI DUE (2) ANNI CON NOTEVOLE SUCCESSO. SIA IL SIGNOR CHRISTOPHERSEN CHE IL DOTTOR OYE CREDONO CHE I SINTOMI MOSTRATI FOSSERO ESTREMAMENTE SIMILI A QUELLI DI ALCUNE VITTIME DELLA SINDROME DELLA GUERRA DEL GOLFO.
IL DOTTOR OYE CREDE CHE POTREBBE ESSERE POSSIBILE CURARE ALCUNI DEI PAZIENTI DEL GOLFO CON UN'ANALOGA ANTIDOTOTERAPIA.
2. SIGNOR CHRISTOPHERSEN E SUA MOGLIE SI AMMALARONO DOPO L'INGESTIONE DI "CAPELIN" ( UN CIBO PER PESCI A BASE DI UN UN PICCOLO SALMONIDE, MALLOTUS VILLOSUS) CONTENENTE ETHOXIQUIN. NONOSTANTE CHE L'ETHOXIQUIN SIA MOLTO USATO COME ANTIOSSIDANTE NEL CIBO PER ANIMALI (PRIMARIAMENTE PER PESCI) E SIA USATO COME FUNGICIDA PER MELE E PERE, NON E' PERMESSO USARLO NEI CIBI. DOPO DUE (2) SETTIMANE DI INGESTIONE DI ETHOXIQUIN SIA CHRISTOPHERSEN CHE LA MOGLIE SVILUPPARONO SPASMI AI MUSCOLI DELLO SCHELETRO E DOLORE.
3. (U) IL SIGNOR CHRISTOPHERSEN HA SOFFERTO DI NEUROPATIA PERIFERICA CON FORTE PARESTESIA ALL'AVAMBRACCIO SINISTRO E ALLA MANO. UNA MODERATA PERDITA DELLA SENSIBILITA' CUTANEA E' AVVENUTA ALLA MANO SINISTRA. LA MOGLIE DI CHRISTOPHERSEN NON HA SVILUPPATO SINTOMI NEUROLOGICI, COMUNQUE, EBBE ALTRI SINTOMI ( EDEMA ALLA CAVIGLIA, RESPIRO AFFANNOSO E ANGINA PECTORIS).
4. IL DOTTOR PROVO' UNA TERAPIA CON DUE (2) DIFFERENTI SOSTANZE, SELENIO E UBIQUINONE (COENZIMA Q10).
(...)

5. (U) DOPO L'INIZIO DEL TRATTAMENTO CI VOLLERO APPROSSIMATIVAMENTE SEI (6) MESI PER LA SCOMPARSA COMPLETA SCOMPARSA DEI SINTOMI DI AVVELENAMENTO DA ETHOXIQUIN NEL SIGNOR CHRISTOPHERSEN MENTRE ESSI DURARONO PIU' A LUNGO IN SUA MOGLIE. IL SIGNOR CHRISTOPHERSEN CREDE CHE L' ETHOXIQUIN SI MANIFESTI NELL'ORGANISMO UMANO IN MODO SIMILE ALL'ERBICIDA "PARAQUAT" FUNZIONANDO COME GENERATORE DI SUPEROSSIDI ANIONICI RADICALI.
6. (U) IL SIGNOR CHRISTOPHERSEN DISPONE DELLA "CARTELLA CLINICA" [CASE HISTORY] DEL TRATTAMENTO E I NOMI E GLI INDIRIZZI DELLE PERSONE CHE POTREBBERO AIUTARE NEL TRATTAMENTO DEI PAZIENTI AFFETTI DA SINDROME DELLA GUERRA DEL GOLFO.
(...)
File: 950719_68720351_94d.txt
Page: 94d
Total Pages: 1
--------------------------------------------------------------------------------
IIR 6 872 0351 94/GULF-WAR SYNDROME (U)
Filename:68720351.94d
ENVELOPE
CDSN = LGX743 MCN = 94214/07203 TOR = 942140554
RTTCZYUW RUEKJCS3825 2140557--RUEALGX.
ZNY
HEADER
R 020557Z AUG 94
FM DIA WASHINGTON DC
INFO RUEADWD/OCSA WASHINGTON DC
RUEAHQA/CSAF WASHINGTON DC
RUEACMC/CMC WASHINGTON DC
RHFPAAA/UTAIS RAMSTEIN AB GE//IN-CMO//
RHDLCNE/CINCUSNAVEUR LONDON UK//N2/N22//
RUETIAQ/MPC FT GEORGE G MEADE MD
RUCQVAB/USCINCSOC INTEL OPS CEN MACDILL AFB FL
RUQYSDG/FOSIF ROTA SP
RUEOFAA/COMJSOC FT BRAGG NC//J2//
RUEHC /SECSTATE WASHINGTON DC
[ (b)(2) ]
RUDMQAN/MARCORINTACT DET QUANTICO VA
RUEALGX/SAFE
R 020555Z AUG 94
FM [ (b)(1) sec 1.3(a)(4) ]
TO RUEKJCS/DIA WASHDC
INFO RUFTAKA/UCIRF AUGSBURG GE
RUEARDF/DIRAFMIC FT DETRICK MD//PAG3-MIC2//
RULYOWA/II MEF DET //G-2//
RUEOAYA/NGIC INTEL OPS CHARLOTTESVILLE VA
RUDMONI/ONI SUITLAND MD//IIR//
RUFOADA/JAC MOLESWORTH RAF MOLESWORTH UK
RUCBSAA/CINCUSACOM NORFOLK VA
RUENAAA/CNO WASHDC//N2//
RUFGAID/USCINCEUR INTEL VAIHINGEN GE
BT
CONTROLS
SERIAL: (U) IIR 6 872 0351 94.
/*********** THIS IS A COMBINED MESSAGE ************/
BODY
COUNTRY: (U) NORWAY (NO).
SUBJECT: IIR 6 872 0351 94/GULF-WAR SYNDROME (U)
WARNING: (U) THIS IS AN INFORMATION REPORT, NOT FINALLY EVALUATED INTELLIGENCE.
--------------------------------------------------------
- DEPARTMENT OF DEFENSE
--------------------------------------------------------
DOI: (U) 940611.
REQS: (U) [ b.2. ] SOURCE: (U) OPEN SOURCE, LETTER RECEIVED FROM HOST COUNTRY SCIENTIST WITH DIRECT ACCESS TO INFORMATION PROVIDED. RELIABILITY OF INFORMATION IS UNSUBSTANTIATED.
SUMMARY: (U) A NORWEGIAN SCIENTIST CLAIMS TO HAVE EXPERIENCED SYMPTOMS SIMILAR TO THOSE CALLED GULF WAR SYNDROME. THE SYMPTOMS WERE TREATED WITH HIGH DOSAGES OF AN ANTIDOTE AND AFTER TWO (2) YEARS THE PATIENT EXPERIENCED SIGNIFICANT IMPROVEMENT. ENCLOSURES.
TEXT: 1. (U) DOCTOR OLAV ALBERT ((CHRISTOPHERSEN)), A NORWEGIAN SCIENTIST, STATES IN A LETTER THAT HE AND HIS WIFE BECAME ILL DURING 910000 AFTER THE INGESTION OF A SYNTHETIC LIPID-SOLUBLE ANTIOXIDANT CONTAINING ETHOXYQUIN. PROFESSOR IVAR ((OYE)), WORKING AT THE INSTITUTE OF PHARMACOLOGY, UNIVERSITY OF OSLO, TREATED BOTH PERSONS BY PROVIDING ANTIDOTE THERAPY OVER A PERIOD OF TWO(2) YEARS WITH NOTABLE SUCCESS. BOTH MR. CHRISTOPHERSEN AND DR. OYE BELIEVE THAT THE SYMPTOMS EXHIBITED WERE REMARKABLY SIMILAR TO THOSE EXHIBITED BY SOME VICTIMS OF THE GULF-WAR SYNDROME. DR. OYE BELIEVES THAT IT MAY BE POSSIBLE TO TREAT SOME OF THE GULF WAR PATIENTS BY PROVIDING SIMILAR ANTIDOTE THERAPY.
2. MR. CHRISTOPHERSEN AND HIS WIFE BECAME ILL AFTER INGESTING CAPELIN MEAL (A TYPE OF FISH MEAL MADE FROM SMALL SALMONID FISH, MALLOTUS VILLOSUS) CONTAINING ETHOXYQUIN. ALTHOUGH ETHOXYQUIN IS EXTENSIVELY USED AS AN ANTIOXIDANT IN ANIMAL FEED (PRIMARILY FISH MEAL) AND USED AS A FUNGICIDE FOR SPRAYING APPLES AND PEARS, IT IS NOT PERMITTED FOR USE AS AN ANTIOXIDANT IN FOODS. WITHIN TWO (2) WEEKS OF INGESTION OF THE ETHOXYQUIN FISH MEAL, BOTH CHRISTOPHERSEN AND HIS WIFE DEVELOPED SKELETAL MUSCLE SPASMS AND PAIN.
3. (U) MR. CHRISTOPHERSEN SUFFERED PERIPHERAL NEUROPATHY WITH STRONG PARESTHESIA IN THE LEFT LOWER ARM AND HAND. A MODERATE LOSS OF CUTANEOUS SENSIBILITY ALSO OCCURRED ON THE LEFT HAND. CHRISTOPHERSEN'S WIFE DEVELOPED NO NEUROLOGICAL SYMPTOMS, HOWEVER, SHE HAD OTHER SYMPTOMS (ANKLE OEDEMA, SHORTNESS OF BREATH AND ANGINA PECTORIS).
4. (U) DR. OYE TRIED ANTIDOTE THERAPY WITH TWO (2) DIFFERENT SUBSTANCES, SELENIUM AND UBIQUINONE (COENZYME Q10). THE UBIQUINONE WAS EXPECTED TO FUNCTION AS A COMPETITIVE INHIBITOR OF ETHOXYQUIN RADICAL REDUCTION BY REDUCING THE RATE OF SUPEROXIDE ANION RADICAL GENERATION. A HIGH DOSAGE OF SELENIUM WAS ADMINISTERED AS A PRECAUTION AGAINST MUSCLE-SKELETAL DAMAGE RESULTING FROM ABNORMAL STATIC LOADS ON THE MUSCLE-SKELETON SYSTEM.
5. (U) AFTER TREATMENT BEGAN, IT TOOK APPROXIMATELY SIX (6) MONTHS FOR SYMPTOMS OF THE ETHOXYQUIN POISONING TO COMPLETELY DISAPPEAR IN MR. CHRISTOPHERSEN WHILE SYMPTOMS REMAINED LONGER IN THE HIS WIFE. MR. CHRISTOPHERSEN BELIEVES THAT ETHOXYQUIN MANIFESTS ITSELF IN THE HUMAN BODY SIMILARLY TO THE HERBICIDE PARAQUAT BY FUNCTIONING AS A GENERATOR OF SUPEROXIDE ANION RADICALS.
6. (U) MR. CHRISTOPHERSEN PROVIDED A CASE HISTORY OF THE TREATMENT (ENCLOSURE 1.) AND THE NAMES/ADDRESSES OF OTHER PEOPLE WHICH MIGHT BE OF ASSISTANCE IN THE COOPERATION/TREATMENT OF GULF WAR SYNDROME PATIENTS:
PROFESSOR PER ((JYNGE)), INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, THE UNIVERSITY OF TRONDHEIM, 7055 DRAGVOLL, NORWAY (TELEPHONE 47 73 59 88 41 / 85 50).
PROFESSOR KARL ERIK ((ZACHARIASSEN)), INSTITUTE OF ZOOLOGY, UNIVERSITY OF TRONDHEIM, 7055 DRAGVOLL, NORWAY (TELEPHONE - 47 73 59 62 99).
PROFESSOR IVAR OYE, INSTITUTE OF PHARMACOLOGY, UNIVERSITY OF OSLO, POST BOX 1057 BLINDEREN, 0316 OSLO, NORWAY (TELEPHONE: 47 22 85 60 71 / FAX 47 22 85 44 40).
COMMENTS: 1. (U) FIELD COMMENT. [ (b)(1) sec 1.3(a)(4) ]
SPOKE ONLY BRIEFLY
WITH MR. CHRISTOPHERSEN VIA TELEPHONE. INITIALLY, [ (b)(1)
sec 1.3(a)(4) ] BELIEVED THAT THE SOURCE WAS QUITE ELDERLY BECAUSE HE SPOKE IN A QUIET HALTING VOICE, HOWEVER, [ (b)(1) sec 1.3(a)(4) ] WAS SURPRISED TO FINE OUT THAT THE SOURCE IS IN FACT, ONLY 35 YEARS OF AGE. CHRISTOPHEESEN SEEMED GENUINELY CONCERNED AND WANTED TO HELP ANYONE SUFFERING FROM THE GULF WAR SYNDROME. MANY OF THE CHEMICAL NAMES ARE SPELLED AS CHRISTOPHERSEN DID IN HIS REPORT AND THEREFORE, MAY UTILIZE THE NORWEGIAN SPELLING.
//IPSP: (U) PG 2520; PG 2500//.
//COMSOBJ: (U) [ (b)(2) ]
ADMIN

PROJ: (U).
INSTR: (U) [ (b)(2) ]
PREP: (U) [ (b)(6) ]
ENCL: (U) TO FOLLOW: 2 ENCLOSURES.
1. LETTER WRITTEN BY MR OLAV CHRISTOPHERSEN (U), IN ENGLISH, 1 COPY, 3 PAGES, 940611 (U).
2. XEROX COPY, CASE HISTORY OF ETHOXYQUIN POISIONING
(U), IN ENGLISH, 1 COPY, 5 PAGES, UNDATED (U)>
ACQ: (U) [ (b)(2) ]
DISSEM: (U) FIELD: [ (b)(2) ]
BT
#3826
NNNN